News & articles

Do you know about mutations? Instructions:   New genes and proteins are being discovered every year in the landscape of MPN research. Put your genetic know-how to the ultimate test with this advanced-level MPN crossword puzzle. Answers may include gene acronyms, mutations, and numbers, but no hyphens. You can find these answers below.  Answers: Sources:   Guglielmelli, P.,… Read More »Do you know your mutations? Genetics crossword

It is with a heavy heart that we announce the passing of Zhenya Senyak, who has died surrounded by his loving family in Asheville NC, after a long journey with illness. Those who have been in the MPN community for some time will recognize Zhenya’s passing as a watershed event.  His dedication, resolve, and tireless… Read More »Remembering Zhenya Senyak

“This new work from Gaertner et al. is significant and potentially field-changing,” says Anandi Krishnan PhD from Rutgers University, commenting on the new Nature journal study. “This is especially relevant in the context of managing blood disorders such as MPNs.”   The study does not mention ‘cancer’ or ‘myeloproliferation,’ yet its findings may be crucial… Read More »New Study Reveals On-Off Switch for Platelet Production  

Profile: Marina Kremyanskaya MD, PhD Icahn School of Medicine, New York, NY, USA  From Bench to Bedside: Dr. Marina Kremyanskaya’s Mission to Revolutionize MPN Treatment Downplaying a cure “It is an experimental treatment. There is no doubt about it,” Marina Kremyanskaya MD, PhD, states plainly about a new anti-cancer vaccine for patients with myeloproliferative neoplasms… Read More »Marina Kremyanskaya, MD, PhD Research Profile

Profile: Tania Jain, MBBS Johns Hopkins School of Medicine, Baltimore, MD, USA  Introducing Dr. Tania Jain  Dr. Tania Jain’s fascination with science began in her childhood as a way to explain the world around her. However, as she delved deeper into medicine, she gravitated towards a specialty filled with unanswered questions. “What drew me to… Read More »Tania Jain, MBBS Research Profile

Historically, MPNS are diagnosed in adults 60 years or older. In recent years, however, there has been recognition of essential thrombocythemia (ET), polycythemia vera (PF), and primary myelofibrosis (PMF) in adolescents and young adults, often referred to as AYAs.   A recent article in British Journal of Haematology offers a comprehensive review of the literature about AYAs, authored… Read More »Growing knowledge of MPNs in adolescents and young adults  

Need help with MPN related out of pocket expenses?   The PAN Foundation is helping patients with Philadelphia chromosome negative myeloproliferative neoplasms (MPN) afford their out-of-pocket costs. If you’re a patient or caregiver looking for resources to help with your treatment-related costs, we encourage you to learn more about the PAN Foundation and its $3,250 annual… Read More »Need help with MPN related out-of-pocket expenses?

To stay up to date on everything MPNs, patients and their families and caregivers have access to a just updated resource that includes 75 pages of plain language questions, answers, and explanations written specifically for people affected by MPNs. The comprehensive document is based on current clinical practice guidelines created by national leaders in the… Read More »MPN patient guidelines updated by NCCN  

Profile: Vikas Gupta, MD, FRCP, FRCPPath Princess Margaret Cancer Centre University Health Network, Toronto, Canada  How can we best study transplant vs best available non-transplant therapies in myelofibrosis patients? According to Dr. Vikas Gupta, studies have shown that high-risk myelofibrosis (MF) patients appear to have better survival with hematopoietic stem cell transplants (HCT) than with… Read More »Vikas Gupta, MD, FRCP, FRCPPath

The fight against blood cancers has taken a significant step forward with new research into the GADD45g gene. Researchers have uncovered surprising insights into the role of GADD45g in myeloproliferative neoplasms (MPNs), providing scientists with a laundry list of related proteins to examine for potential therapeutic targeting.  A notable study recently published in Nature Communications… Read More »The New MPN Protein: Insights from GADD45g Research