MPN Research Foundation: A legacy of impact Sources Kralovics, R., et al. (2002). Acquired uniparental disomy of chromosome 9p is a frequent stem cell defect in polycythemia vera. Experimental Hematology, 30(3), 229–236. Klampfl, T., et al. (2013). Somatic mutations of calreticulin in myeloproliferative neoplasms. The New England Journal of Medicine, 369(25), 2379–2390. Moliterno, A. R.,… Read More »MPN Research Foundation: A legacy of impact
Blasts 101 — what they are and where they belong Your body constantly makes new blood cells in the bone marrow, a process called hematopoiesis. Blasts are early, still-developing cells that are in a transitionary stage between stem cells and fully mature blood cells. There are two main types of blast cells that make up… Read More »Blasts 101 — what they are and where they belong
Few scientists have a clearer view of where myeloproliferative neoplasm (MPN) research is headed than Dr. Ann Mullally, MD. As a physician-scientist, Division Chief of Hematology at Stanford, and member of the MPN Research Foundation’s Scientific Advisory Board (SAB), she sits at the crossroads of patient care, clinical trials, and discovery science. From this vantage… Read More »From CALR to the cutting edge: Dr. Ann Mullally’s view of the future of MPN Research
What GLP-1 drugs reveal about MPNs, inflammation, and cancer risk A surprising link between inflammation, clonal blood stem cells, and a blockbuster drug opens new questions in blood cancer research. In recent years, glucagon-like peptide-1 receptor agonists (GLP-1RAs) — the class of drugs that includes Ozempic, Wegovy, and others — transformed care for type 2… Read More »What GLP-1 Drugs Reveal About MPNs, Inflammation, and Cancer Risk
What do megakaryocytes, machine learning, and a team of Oxford scientists have in common? They’re all part of Dr. Daniel Royston’s mission to teach computers how to see what pathologists might miss — the secret signs of fibrosis hiding in the bone marrow. In this month’s Researcher Spotlight, step inside a one-of-a-kind laboratory where engineers… Read More »How to train your AI model: Dr. Daniel Royston’s quest to decode the bone marrow
Explaining a chronic cancer like an MPN to a child can feel overwhelming — especially when the symptoms aren’t always visible. In this new article, pediatric psychologist Dr. Joanna Patten shares expert advice on what to say and how to say it. Learn why late is better than never and how honest, age-appropriate conversations help… Read More »How to explain MPNs to children
At the center of translational research, clinical care, and academic leadership, Dr. Gabriela Hobbs, MD is charting a more thoughtful path forward for people living with MPNs. Through collaboration and leadership, she’s transforming every resource into scientific discoveries. “Research can look different in a lot of ways,” Dr. Gabriela Hobbs says with a knowing nod.… Read More »Every sample, every step: How Dr. Gabriela Hobbs is rethinking the transplant journey in MPNs
MPN Pathways: Empowered Voices in Research bonus session — What’s your why? At MPN Research Foundation, we are dedicated to ensuring that the patient’s voice is at the forefront of our work. As we grow in our role as a patient-centered research foundation, we continue to take intentional steps to bridge the intersection of patients,… Read More »MPN Pathways: Empowered Voices in Research Bonus Session Summary — What’s Your Why?
Profile: Brandi Reeves, MDUniversity of North Caroline at Chapel Hill Hematologist discovers the kidneys: One researcher’s quest to explain an overlooked MPN complication It all started with a series of patients who couldn’t qualify for a clinical trial. Not for lack of interest — one after another, patients with myeloproliferative neoplasms (MPNs) couldn’t meet enrollment criteria.… Read More »Hematologist discovers the kidneys: One researcher’s quest to explain an overlooked MPN complication
Profile: Simón Méndez-Ferrer, PhDRutgers University Beyond mutant cells: Dr. Simón Méndez-Ferrer on the role of the bone marrow environment in myelofibrosis (MF). In a healthy body, the bone marrow is a bustling ecosystem, teeming with diverse cellular species, each playing a supportive role and maintaining balance. Stem cells stand at the heart of this environment,… Read More »Dr. Simón Méndez-Ferrer Research Profile
