There is no single treatment that is effective for all Myelofibrosis sufferers. Each patient has a unique set of symptoms and circumstances that require different treatment options, as prescribed by a doctor. Also, some patients with MF remain symptom-free for many years and may not require immediate treatment. However, anyone who has been diagnosed with MF needs to be monitored over time for signs or symptoms that suggest the disease has worsened.
Allogenic Stem Cell Transplantation is the only curative treatment for MF. ASCT, hematopoietic (blood-forming) stem cells are transferred from a donor to the patient, essentially replacing defective stem cells with healthy ones. Before the stem cell infusion, the patient receives chemotherapy and/or radiation therapy to eradicate diseased bone marrow. In an effort to improve stem cell transplant outcomes for MF patients, MPNRF created a Stem Cell Transplant Timing Tool. The SSTT is a portable on-line tool based on a clinically validated scale. It provides a color signal in response to information entered by a patient, that indicates a risk level and median survival times without a stem cell transplant. A patient can then take what they’ve learned and use it to facilitate a meaningful dialogue between themselves and their physician about their treatment options.
Of the MPNs, only those diagnosed with myelofibrosis would be considered for a transplant. Within that population, only a subset of people will be healthy enough to undergo a transplant. Patients need to carefully discuss whether or not they may be eligible for such a procedure, given the complexity and possibility of complications. Since age and the presence of other diseases elevates the risks associated with ASCT, the decision to pursue ASCT should take into consideration the patient’s risk tolerance and transplant-related prognostic score (a rough measure of likely success, based on factors specific to the patient and the transplant).
MPN Forum Roundtable: Stem Cell Transplantation in Myeloproliferative Neoplasms
In an effort to improve stem cell transplant outcomes for MF patients, MPNRF supported the creation of the Myelofibrosis Assessment Graphic Internet Calculator (MAGIC). MAGIC is a portable online tool based on a clinically validated scale. It provides a color signal in response to information entered by a patient, that indicates a risk level and median survival times without a stem cell transplant. A patient can then take what they’ve learned and use it to facilitate a meaningful dialogue between themselves and their physician about their treatment options. SCT Spectrum Transplant Timing tool is available for free on a mobile phone, tablet, and PC.
Below are 6 presentations recorded at the 2018 BMTinfonet.org Celebrating a Second Chance at Life Survivorship Symposium with a multitude of information about how to prepare yourself both mentally and physically for an upcoming bone marrow transplant.
As of 2016, Medicare now provides coverage for stem cell transplant for those patients who need one. The coverage is reserved for myelofibrosis patients who have a Dynamic Prognostic Scoring System intermediate-2 or High primary or secondary MF score. They must also agree to participate in a prospective clinical study to evaluate their outcomes vs patients with the same score who are not undergoing a Stem Cell Transplant.
Read the relevant research articles below about Stem Cell Transplants for MPN patients.
Which Patients with Myelofibrosis Should Receive Allogeneic Stem Cell Transplantation? A Decision Analysis Based on the Systematic Review of 4,341 Patients. Monia Marchetti and Nicolaus Kroeger Blood 2017
Transplant Decisions in Patients with Myelofibrosis: Should Mutations Be the Judge? Salit RB1, Deeg HJ2. Biol Blood Marrow Transplant. 2018 Click here to read more.
Allogeneic Stem Cell Transplantation for Myelofibrosis in 2012 Donal P. McLornan, et al. British Journal of Haematology 29 March 2012
Sources:
Hematopoietic Cell Transplantation as Curative Therapy for Idiopathic Myelofibrosis, Advanced Polycythemia Vera, and Essential Thrombocythemia. H. Joachim Deeg et al. Biology of Blood and Marrow Transplantation, March 2007Volume 13, Issue 3, Pages 355–365
Allogeneic hematopoietic cell transplantation versus drugs in myelofibrosis: the risk-benefit balancing act. A. Tefferi. Bone Marrow Transplantation (2010) 45, 419–421; doi:10.1038/bmt.2009.193 http://www.nature.com/bmt/journal/v45/n3/full/bmt2009193a.html#bib1
Join our community to get the latest research, patient stories, and exclusive content delivered right to your inbox. Plus, when you subscribe, receive the latest NCCN guidelines and resources to support your journey.
JOIN OVER 20,000 SUBSCRIBERS. UNSUBSCRIBE ANYTIME.